	   SnapGene      #acgcgtgtagtcttatgcaatactcttgtagtcttgcaacatggtaacgatgagttagcaacatgccttacaaggagagaaaaagcaccgtgcatgccgattggtggaagtaaggtggtacgatcgtgccttattaggaaggcaacagacgggtctgacatggattggacgaaccactgaattgccgcattgcagagatattgtatttaagtgcctagctcgatacaataaacgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtggcgcccgaacagggacctgaaagcgaaagggaaaccagagctctctcgacgcaggactcggcttgctgaagcgcgcacggcaagaggcgaggggcggcgactggtgagtacgccaaaaattttgactagcggaggctagaaggagagagatgggtgcgagagcgtcagtattaagcgggggagaattagatcgcgatgggaaaaaattcggttaaggccagggggaaagaaaaaatataaattaaaacatatagtatgggcaagcagggagctagaacgattcgcagttaatcctggcctgttagaaacatcagaaggctgtagacaaatactgggacagctacaaccatcccttcagacaggatcagaagaacttagatcattatataatacagtagcaaccctctattgtgtgcatcaaaggatagagataaaagacaccaaggaagctttagacaagatagaggaagagcaaaacaaaagtaagaccaccgcacagcaagcggccactgatcttcagacctggaggaggagatatgagggacaattggagaagtgaattatataaatataaagtagtaaaaattgaaccattaggagtagcacccaccaaggcaaagagaagagtggtgcagagagaaaaaagagcagtgggaataggagctttgttccttgggttcttgggagcagcaggaagcactatgggcgcagcctcaatgacgctgacggtacaggccagacaattattgtctggtatagtgcagcagcagaacaatttgctgagggctattgaggcgcaacagcatctgttgcaactcacagtctggggcatcaagcagctccaggcaagaatcctggctgtggaaagatacctaaaggatcaacagctcctggggatttggggttgctctggaaaactcatttgcaccactgctgtgccttggaatgctagttggagtaataaatctctggaacagattggaatcacacgacctggatggagtgggacagagaaattaacaattacacaagcttaatacactccttaattgaagaatcgcaaaaccagcaagaaaagaatgaacaagaattattggaattagataaatgggcaagtttgtggaattggtttaacataacaaattggctgtggtatataaaattattcataatgatagtaggaggcttggtaggtttaagaatagtttttgctgtactttctatagtgaatagagttaggcagggatattcaccattatcgtttcagacccacctcccaaccccgaggggacccgacaggcccgaaggaatagaagaagaaggtggagagagagacagagacagatccattcgattagtgaacggatctcgacggtATCGGTtaacttttaaaagaaaaggggggattggggggtacagtgcaggggaaagaatagtagacataatagcaacagacatacaaactaaagaattacaaaaacaaattacaaaaattcaaaattttatcgatactagtattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtTtatataagcagagctcgtttagtgaaccgtcagatcgcctggagacgccatccacgctgttttgacctccatagaagattctagagctagcCTGATACGAACTCGgaattccctggccgtggggtcagctgcacaggccaggagctcgagggtggtggctggcagaaagtgcagtccaaagtactctgttttgttttgattgtgttttaaaatgggacaaataacagcatgtgtgtttgctgatggggagaatccaggagaaaaacagtgaagttgaggtgagcctcacagggtcagggggaagacaggggatcccgaagataacgtctgctacgaactcaattgcatccgccccgggccctaagttgaagccctaatccccacgttgactgcatttggagaaggaccttcagcacatgatggagggaccgagatgcccaaatcctggccctcctgctggactttcattttaaagaacaataaaattaatgttaacttctagcagcttccaagctctgtggccccggagagggtcagcgaggggcctccactgtctgagtccgctcctggcaacgcctgctctctgcactcagaggcccggtcccggcagctgccacgttgctcagaagttctggcagggggagcctgaaacccctgtctgctggcgacactcccggagcagcaggaaatctctacattttattttttttcttaacagacaaaagtatttgactccagaatgatttccaggaattacagtatgagaacttagtctttgagatttttattttcttcttaaaaaaataaaaatgaaatcaaagcagaagacactggttgagcagacagcacactagcacattccacttcgcaacaaaacctgcgtggatccCTGCGATATCCAGCgcggccgcGaaggatctgcgatcgctccggtgcccgtcagtgggcagagcgcacatcgcccacagtccccgagaagttggggggaggggtcggcaattgaacgggtgcctagagaaggtggcgcggggtaaactgggaaagtgatgtcgtgtactggctccgcctttttcccgagggtgggggagaaccgtatataagtgcagtagtcgccgtgaacgttctttttcgcaacgggtttgccgccagaacacagctgaagcttcgaggggctcgcatctctccttcacgcgcccgccgccctacctgaggccgccatccacgccggttgagtcgcgttctgccgcctcccgcctgtggtgcctcctgaactgcgtccgccgtctaggtaagtttaaagctcaggtcgagaccgggcctttgtccggcgctcccttggagcctacctagactcagccggctctccacgctttgcctgaccctgcttgctcaactctacgtctttgtttcgttttctgttctgcgccgttacagatccaagctgtgaccggcgcctacgctagacgccaccatggagagcgacgagagcggcctgcccgccatggagatcgagtgccgcatcaccggcaccctgaacggcgtggagttcgagctggtgggcggcggagagggcacccccaagcagggccgcatgaccaacaagatgaagagcaccaaaggcgccctgaccttcagcccctacctgctgagccacgtgatgggctacggcttctaccacttcggcacctaccccagcggctacgagaaccccttcctgcacgccatcaacaacggcggctacaccaacacccgcatcgagaagtacgaggacggcggcgtgctgcacgtgagcttcagctaccgctacgaggccggccgcgtgatcggcgacttcaaggtggtgggcaccggcttccccgaggacagcgtgatcttcaccgacaagatcatccgcagcaacgccaccgtggagcacctgcaccccatgggcgataacgtgctggtgggcagcttcgcccgcaccttcagcctgcgcgacggcggctactacagcttcgtggtggacagccacatgcacttcaagagcgccatccaccccagcatcctgcagaacgggggccccatgttcgccttccgccgcgtggaggagctgcacagcaacaccgagctgggcatcgtggagtaccagcacgccttcaagacccccatcgccttcgccagatcccgcgctcagtcgtccaattctgccgtggacggcaccgccggacccggctccaccggatctcgcgagggcagaggaagtcttctaacatgcggtgacgtggaggagaatcccggccctatgaccgagtacaagcccacggtgcgcctcgccacccgcgacgacgtccccagggccgtacgcaccctcgccgccgcgttcgccgactaccccgccacgcgccacaccgtcgatccggaccgccacatcgagcgggtcaccgagctgcaagaactcttcctcacgcgcgtcgggctcgacatcggcaaggtgtgggtcgcggacgacggcgccgcggtggcggtctggaccacgccggagagcgtcgaagcgggggcggtgttcgccgagatcggcccgcgcatggccgagttgagcggttcccggctggccgcgcagcaacagatggaaggcctcctggcgccgcaccggcccaaggagcccgcgtggttcctggccaccgtcggcgtctcgcccgaccaccagggcaagggtctgggcagcgccgtcgtgctccccggagtggaggcggccgagcgcgccggggtgcccgccttcctggagacctccgcgccccgcaacctccccttctacgagcggctcggcttcaccgtcaccgccgacgtcgaggtgcccgaaggaccgcgcacctggtgcatgacccgcaagcccggtgcctgaaatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaagctgacgtcctttccatggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtctccgccttcgccctcagacgagtcggatctccctttggccgcctccccgcctggtacctttaagaccaatgacttacaaggcagctgtagatcttagccactttttaaaagaaaaggggggactggaagggctaattcactcccaacgaaaataagatctgctttttgcttgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtagtagttcatgtcatcttattattcagtatttataacttgcaaagaaatgaatatcagagagtgagaggaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggctctagctatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctcggcctctgagctattccagaagtagtgaggaggcttttttggaggcctagacttttgcagagacggcccaaattcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaaggacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtctaagaaaccattattatcatgacattaacctataaaaataggcgtatcacgaggccctttcgtctcgcgcgtttcggtgatgacggtgaaaacctctgacacatgcagctcccggagacggtcacagcttgtctgtaagcggatgccgggagcagacaagcccgtcagggcgcgtcagcgggtgttggcgggtgtcggggctggcttaactatgcggcatcagagcagattgtactgagagtgcaccatatgcggtgtgaaataccgcacagatgcgtaaggagaaaataccgcatcaggcgccattcgccattcaggctgcgcaactgttgggaagggcgatcggtgcgggcctcttcgctattacgccagctggcgaaagggggatgtgctgcaaggcgattaagttgggtaacgccagggttttcccagtcacgacgttgtaaaacgacggccagtgccaagctg  L5   5   2      *   7   0         /            4   '   +   2   -   7      1   4   -                   +   !   "      "   5          *               '      #                   /         .   8   0      '   6      '   6   0   -   8   0   -   *      +   1   <   )   #   '   $   !      "   8   5      -   .   #   )   2   W   1         &   (         $   $                     %         #   %            #      %            !   ,   &                  !   #   "       !   -   /   -   +   %   !      $   '      "         )   ,   -                  (               $                  #      !   )      &   %      '       >   %   !   "      '            #   /              0      "   #      $   "   '         $   8   '            !             '   $   $   K   '   7   $   :   )   *      %             %            1   >   %   $   4                     +   1      *   +   /   '         H   )         /   8      .   "   4   !   #   ,        5 ûQR}~Ú%§!"#0	‹	¿	À	Ê	³
lmnsšÐÑ'œ�{|NÌ4]efg*—Í	 !	"Â"Ã"2 ¬½Sf«î½-K�{¨1¥1M�l	Œ	Á	Ë	?
o¤Òì^—hÁÕj˜òÂaÌ™ Ø!�"Ä" – é 8C&$	,	¹	©
t„›ÌAO¢+Îs á !ø!"Þ"é"* ü¢`°Ûöõ{ú	´
G(¹¬¸ÇÉ/žÔL´+} Í5Br­_Æ"
 ¡ ì!
"•"¢"7 I 	#.T¬­°³Æõ4L[ˆ=Í2�¿#	�	—	$
<
¤
:pÓÐXv�³¹¼Ýmplä6;_…ÂŸ«™Ã¶!Ù!]"0 i ˆ �¾g€]r.Uÿ0Okuè»2ÿÂ	C„¥SÆ_nÖHœk%JÐMÞbû‚ š ª ‘" ¡ 
G„|ôûÌ	
)Aã#Œ
ýÖ­óÍ ô Ñ!Å" ¦ ­Öï¾Ž©¦Nm	*
@
a
~Ûh%2ôHb®í/˜Ài²!/ f q 9ÊÙŒ-	0	¬	:…’Í�©ÃÆ,ee”<W�P¤»Ï¦T,¡Gð€§ƒt �!™!ù!"B"�" * t jx‘ Eþ%œžÿ&#ë :�ªÏå,Yzºß" ó rD'Iá“×a©ïrÈ¬¶û¡ƒÏCâ !ê" — ê 	º	ª
î
u¯B]£ÖÖMÏúV3¼!4  öý aºö|ƒ.•Å@˜­°é[‚…¸QOZ~Ò >¡ž®äýc¤Ã íß«Á ¢ m!í!ÿ!o"–"»"Ò"' Œ ï£Üí÷w´ç>7	Ï
ô
HyŒ¹(Ê0Õ)M7!™ÎCAÂhuŸI† "+ Ü&Ý±ù@3	¹)å7^ÐT8,°…ŠR6;tÛsÌ W¢Þq`Çü¿""�"2 xÈ™~³			û	U
ž
µ
é
 QºhÈ¨¬Ÿzµ‘œ´ÊÝöA�±Ðãtzƒ®ÃŒ:EW	Ó#.y!£"	#- ôù$p®±»®¸>¥‘*	ª	=
§
±
ç
qÊ%O¶|¦ÙºJQn<¢ƒšrx� ¬œŸãsÄw!7 J L Â r/13>UL´Ç“ÎÐÒÔÚÀŽ	˜	%
E
¥
‘ d�Ô³Ybw´=sqm‹`+’˜¾š ìœ* ·!1"^" 3 A
ö\‰q3Ã
e}žÞ† 7†ú”6ŸùTLjâ†²3"1 
Æ@­v&5M¡ê$	¯	;ÛLÑ[d¤ß“}½Ïo¥åE�»ÃŠ:ç2‚ß'w ð Ú!#"4 j ‰ ä+Ú^sÉV¼¸ÁÄÇà¤	Ã	Ó	
'
Î&f�ÜuTvÇ«`o•Ñ=¶/.c$ƒ Ô ’"- N �³¹¿h�…Ñ 1•Ñ3;	š	DÂ¦Öó`…I…ël&§N¥ãü « !1!H!œ!G"`"¾" ² WÎ/òPv¿ÖàéPl¼7] 	�	x…sŠ‡ž› ³  !  ª §³ì¢lÚð®ùå	q
“€Öó‹”?˜×�*Klßä 0 5c…Üˆ	9
G
¬ÙÃr6 “!Ò!T"Æ" Ä Ý HNl¶ï6}„üôÖ	!$¼þ´½äÎõ  b ¢ · qéã\	|¢ä÷�×šô("Õ"+ y ý t] àõ·Í	*10y´äóBï�K�¶-c®¹Á„Ùë , P ™"! “ § Ðouû(rÂM_N&h§ªILœ¹f™À’Ô?!–!¹!ù"#" œ äðUg¿ƒ�¯ÖÜ?Nn	Æ	1dÑàÜîi10I®¯"[¥ Y!¦!ß! d×§O
b
qÜ»Ôûî8j[´È³´¤" ø }®‡¨“ª�Ö+
A
µø<Ðñò3‚õcb¯ÂÁ1±6í~î®5 g r �ž+ý‹ Ëù�	.	1	œ
E“Î›ªÄÇ	-cf·Û#k?Xí9!‹Ÿ¤RFù¢�Ü1¥ bÌjîÚ¬¢	­	ªñ:‘²âfñ–›é80q}„u ‘!š!E"   OQ`‹;†`	}		²=‚§°U€
DçHd¯¨5£ú!"C"* Y } Ò CS:=—H+?	;†ã‚ˆ'•-Q¥¼Ð©ü-vÜfñÚøïD 6!5"ž"É"#   Lá+àø:F<€èHWZ˜7JêZ{±p + m kƒã^_�Ÿ$Î!P‘«ÐNl'n9 Ë!Y"à"ÿ" Ê Hž’!ÿ‹Âk�Û :Ngs¨ì;æ&-D»¥!p! u y^&—¸ëˆK	´xàˆ¹'�ˆ,"' ]É(X§	

 Øib¢sˆ’É?W‚öO]V�[��õ+´' ° ü!�"Û"ü" 5 ô s¿Ís�
*­·ñ	Dí_{ä7Dã # ü	JU�â59”§ÑR	W	b	�	£²£üà¢fÆ„Œ2‚¶m ‹!ë" <E÷l  §Í„ªð]@ÚèCQuû’sÐ 2 ! \v¯ëg°ì(Csý*ŸZgs×N¬³" ‡DÈ+³	»	«
A“•Þ@c×›ûª b”Ä½!è!ò!ô"  	  ˜ ë Y�ÖÜ	¿
'š™W^yï¤šÐW‰Pé B!‚!Ç! D	Å
ï
^’Á­iœ© ¡4/ þ!O—ß }˜f®±5\ƒRcFU[y§?ƒ•¾Îá•Ÿâéþî~©ò Ï!ö! ""@" " ·÷<a¯
/$/]¹LH¥å¥á‚êà¬ £ —"¼"Ó"  B÷„j�™†°àµË&që¢íM¦[dÄÂk n!‰!ð!W". ¡çéb»N–=Æ%AêJ—â$P–¸Ó%GIi³“R“¯ÐÞ!…3 )†×#!‡!î!p"…"8 ¿ ›Ó¨¼(ORd™œŸäx-µèž8	A	Œ
õ
=@ËÝIåÄû1•Nº"BTªo»"ÃÆÜ”—¢+2Já­!Ü!%"0  # 9 � ð¤.x“½ÌîÄÍøHuÐ
úzþÇ8½pÇš¼€Ã4?i�ß9ˆúy ‡ ‘ ‡"Î" [ º ?ÃÝy	ï	
.„ÌnŽÖ˜¾ÏÉàî„ RX × "i"' T ëŽûY=?	3
à
äìP�ºá)K�Ë=tÂæ*½Øµ«DhvMF %!7"O"6 áÞr«úE[Î	4	…	^
ø
+7¦Š)¿Ñ±)v¶),<cuÕEXÝ|Íß`4\a‚:wÜ$ "‚"¸"Ë"# '¯ô²TÎìà	I8_›¡UA¤tÍ'Œ<óf™¬"' '8EÝa7¨A�
 ïþ•Ñ4^‹,GSõ’™àñþ­£_¹ö#hÈÀuÃ!"6 Ù Èç+£&	—
É
Ù
5º*ªÈæ9-/†â7xÜÅ!øT±ÁÒòr•Ôà.U5]×õý¯Ê	·ñ°!0 _ · 
	!îCR^q–â'�É©­² /¶ÅÈÑRiˆ�µÕ'BK™Øu{Xó$^/Ž Õ!- yšÅ	û
UPqOm�žÝäù÷Ô…Rx�;F¼É@w“gÙ8!r"y"´"å"
##8 @  Ô -<ÉgJ»ð±	¶
Õ
ˆ¿t{„»ÓôCiF«êü™ËWÒ4 |Ñäõ"½æõ~„¯&/	‡
 E¤"0 U£´’jõ	ü		
J
V
Ÿ
ê
=W?Fmìù9 {Ž’ÞçSk§ËŽ%²û/;EPÄ[wzÔ½z!ä!- «¼ú|ª¼¯z¦/+	¸	¾	É	>
¨
²
rË&·ÆK³3dqÔñÅ!˜   à !ë!”"Á"è"* H ‡ Õ-	F\q¯²ô3T<º"	–	)
Bƒ(}Ú»Roã­„›ž$I±Õ ¬ � \" p HÉ’«	‘�®Â;£ 9Lä+ ‹ õ%wÜ}¹ì?v²‚	è
Pè§É=˜@sy¡­�ü9DVpÂìtžÞ… l!x!n"€"Ñ"1 K Á qÅó02?Kou%’pÏÑÓÙ é¦
æ
KŒZcµÞ|Pn*‘“™q½›žÞøSi""2"< M *V„²ÐÙÈ¡ñ”¾ÐÕßOÀÃÆ6\ß:	�	™	&
p
w’ÍeŽÕ>t—r_„”)¤µ-#�ã
!G!_") Ã ü s4\Mkµpîß¶âÕ	F
¡/xØòŒÂöJŒµ,»™¸³q+ '"S"# ’ ÷ |ãTf†§‚’ÕÛ>MÁÅ	cÐß´ÛLña0°5³¿®í¸!Þ!' Ñ BNŠ�Ë*–Šií*«>	¡	D©â~8ûC•š7ÛpÙ04¢î5!4"#$ l KG�*‚ßâ÷]9;Š–·êJ	jŒçwß‡VYr—%CMko&‡! 4 ¾WûTr4¦	

h¢Ÿ¡‡\õ?BúCU1^œrz�ã*³1 Ú"   †ÕÇC	Ä
™]êfV?fš O“ó"" ¶æ AN–ÿ®
M\e4ß~px¦$F‚½èà}�(j ñ Î!õ!8 8 S š§-w’ú'NQX›žÂãÌG�x	2
‹
<?ÊÜãëÃàý�Æå¼SÂÈß3>ƒÅÛ“–LàW x Ö Û!$"5 Ø 7Ç®ó`6æ§¢ë	%	Ž
–
÷
©6¥”š3]¾ÐábDÄð¬&‹Ü;{ñÓ-[\eÉ¯!Â!·"# ,fï°	
ÒáøEl�æÊQ¼å%yÈ?ã!- G o Š »,vÛE[¹È(
'�çÁ:Èâ¬?cpû8CU«ð Ý „ — Ÿ ["“"À"Ð". òƒSjt…
$ð½ÏÔÞNÂÅ5[áÄ	Ô	o
Ï×Ýñ{ðõ/^‹ƒ(º­R´·pF!# k Ð J�ÊÞú=	I	¥	
	ig¨á¡vU–™0B/n%)’í4!Ù") R +6µåM¦_•Wâ¦œ
•
É¨5ÂŒwÉaäïÁÞ$ÒZ>’d Õ Í!â!#2 Q 5´º‚DR€Ý	#Ó4Z<	H	n
hÈ§§æô]bî‚ÀÝ#ú'7BT¹QªAÿì– 3!¿"W O P ‘ijk†‡ˆ”Qzåæ !"2ÆÒ'deqryDWg	›	œ	x
g´µ¶·¼½ÿê\a†J6ARS‹ŒOP¦§¨©ä	
)*üýþëý { | ‰ “ ” • !!2!f!g!�!a"#1 ’l‰�ç×çc–ò(jszEXwh	q	N
y
E¸¾Ã×ëk‡K†¼ÐÙÈì�$+7Š ¬ !!h!H"b" å À•Ò{3ÇUf�	 Ÿm¨koåPþ } !I!ž!# lQ×ó3ò.Yxi	~
y¿15‡³3„,eá‹ ­ !&  â 2Šè%Ø0`¬Qm½8Dr	u
¹ˆë‹½ÅÚ~ŸÇÑœ ´ Ë !!i!I"c"( ³ Xm�ÂÏè†¦—ž¸áê)^kt{	ë	z
†|ìLwÑ_ÉíþI%WV “ÂódwÀF‘	
O
FÄtØl¸LÐˆŽ8<l - æ ´ñJÙ	Ò
�ô•X $™œ‚�àŠÖÿâ"#$ % ; � ¨–Ó|£¿m›ÛJgau	ž	r
`üÔUgÉ^¿+Òl~ !$ mÎ4Vdúæ	„
” ŒÐ&{ž5?“æQ·;å L "‰" « Áù0íÈŸ¯ ×@rÜ¾ØnL©m¥pŽ; J!_!Ÿ! ( Ÿ 6d ^†ô£×ó/yj	‰	:
VtšÄPr´UÔ½AG 1 ¹mØ4›7
z�ÀÎÚ€À�6ˆ4…þ-Jâéî W!”! Z{	
­¥a.èó7 ® !Ç"  > ] R�ÝH
ra2?mfes§Œ «!Ó!">"U" ›Im1”7Rgn¾9EýÝÆÚn+š Þ!j!% ã 3�#OÕÛað%1Bšs	×	v
ºß"i‰ìy±¾Û·µTÏ� !d! Å ‹™!·ÓÙ#~˜ÝŒFHÌ ú <"  Þ é&­Q…õ%½ÿ¾åÈÒµ » ö J"d"# c £ ´ ¼ Ç 8ÃéŠµr¹å%o]	ì	}øDÑ§îJªX–øÑ æ )"% „ JY‘Ðñ‡˜Ÿâë*‡ê_l�ÄÑ{
‡åkF�Ø›&TÎ N!Q!\!¯"Ö" Ì §!9| 
i
OTm}£©íYuÒâ`i(õ�Ù ü !)! n¸-€åuä	ðMŽxnðI�ÊÿÅW—u"|" z ^ÁŠ�Ë¸2TzpµØùþ4Ž‰�—¹¢š"# ÖAßxïGÅ†RôÙ<ŽË
Ñî†9mÚ:õÝ T!r!"k" þ ”¡Åeö¼G+0åCLŽ·Mf=/¯Â=|…Ï Q Z % uÃýôáÈ’	Î	ñ	
P
X1÷„�uðm¹.*ôŒdº–AKìj-  ” ç ívòüKŠ‚–Y€Oš'’M
ÁËÀÊ¨ —!º!# . w ¨ µ}÷ã	`;z¤¨Jƒ€j²á»×u!÷"# À)Ú	
þ
õ�%i«��gš§ë‹  @!ú"!   ÑpsÃÌÓ
;\íGNMè»à"g'º‘ “2žÕó­²"ã", � ©ñ(�{ÀÓn�°×Ý(K	v	Ÿ	¶	Ç	aŠá[-Ý[jÄÀ1¯Óö#\œ À!Q"& E à å÷h}À„¤œ¤ÜSbhobo	s
eýÕVïŠèJ=ºÎ×ü‰m!à! & < � —Ô@O™ºí5
MîRp_ü2	D,çÜø '!Z!©! V{¢¯2ÒæbhÊç°¦ §! ¯ $ë�B
¼
Ô¡¶�ü­ÅFkŸÝëXÅ¿ÌO_€M ."Š" n[W‡èXÕ	Ñ'\´”¸" `	¨°Pc
…
•õ#¼vï9U|ŸµµR<æa !  eØÏ5±eûM	ç	â
4rÝ|6@Éöç¥=Š @ · ½ # V ‹°B
Ø¶=‰žÍëÌ,>ƒéö
Úú�–°Mútçù¯Ô! L"f"" ¬ ù ÂúXˆî?É„ÔASÑã dâd×2²¿qbÌ�g K!9"  ¯©€˜ž×,
K×òÿ+?cs·ÝÚˆÂ)oGx;!`! !!  ~1ý” « !ù�¼/Ajˆó4¡¿ØÃ¿Ù7ªîn¦ï< H - 7e¡í,BJ_Ù$Œõ ¤ô0zŽ	k	Š	Fk£Ï«È.Ó@ËA¡À)¬^r �"Ý"/ h   ¥ Ž¬Åþ/NZjtƒ‡çÌú¾#
;
`
	ÏWuœ
g¸Ü$laÅ:^â".‹mGªÏÝú- ) e s ò i�DØ/	Ö€¨Å+dîºþq¥ÇS%«"µúÕÎ+Xy‚ùU2¦¹B‚+ ŸÇø³æ=	2	6	T
�
Î
-”¸Y›³ÑõQŒ sËVb£ÁÒ¾-Hþ!"º"% 2 @	º­·©	®	Â
�ŸÚNd’¤‚ºù—‰œ591žÿKr…›) v ï 0"! ± ²ãÍë»Ùkï­£	
ÁòŠ“ÛÕò‰ê† <.² Ó ÿ ›!F" Ÿ5Ûó[	‡	8
{«³ãbÀãêO ’!$ › cntœ'qÕ
p÷;Ïðg�Áú¸He7ZÇ~ÓZ£~>!X!•!¥!' PR_aŒ:<üGÿ_	|	~	›
~9>ð Š¨¯	Eøæè/ce÷|D"È"   É à]‡³9fGœ 6Ié°¤8 !Ê!+"þ"" \Ì;È8ÐQ	V	a	€	€
¦ƒ±>V�¢ßðç‹Z�ô6& ¯ û!Œ" Œ[¾
&®Àx”ÝYbÿrˆ©aè Æ!" ;Þ.�$Ib–’àLQ¥ÏáÝ„2…¨"?"V"„"Ÿ")  " Z ¾ >˜Ë<,	@	î	
ß
äJŒs”Á½ª©ínº~g�Þ8ùQE ¬!6"Í", &Dàª*DSZ„	ß	]
Ø
*ý‰(.+@Fuµ+w£Ô‘˜ßý_ò9gÛ˜t¶ðÊ"- ? ^ ~ ¶ Ó ;TI‘I
ú
<‡pƒól€R¦Ñ3Ó$„×ô.ZwòŸ]’f¼� 7!Ô!# † ó2;Gu�œÓo8Kë!k! ö p)[±ÏâJenío¿=Þè‹ÚKI¯)²²h	!   M…œá•V8Shì:‰Æª˜é>X[ô™›q€¡ 7 × ™,ùFþîŠ
êPRÇ%Û,Ú[|ß n Ï *Lu„M› 
à .Šã¬ïm(ož E!Ì!Z"Ø"( ä 4Ž“PÖÜä
bñ&Yf	m
w
³»ž¦j[í¿Ü"Q¸#(6@Oê!e! # Á$_«·2C
}
0v²^Ï2HƒkV}UÐ , lš`t	Ø	ƒ
_#]Ï%z4>’Ñ¶: ^!"á"  Ÿ¸]�¢ŽO€lçI¼F¦"=" Œš "ÒÔÚ“"$f—™ÜÞhx°¶EGc!$ ƒ Æ Ë I7‰´ä,ŒÃÐSl¨Cjmt¦hŽ©'ŒSÍ Ð å û !P!®" ‰ €;�)óí<‹–¸.{@9Ü S!q! v ¿‰öâ	F:y£º~&¦�Êº¿É±" D ß ö'z¡®'Ran˜¹ìL‰,aZ‰ç<¹õ›æ÷   ê_†¯L	µWž^‰` ¶ ¼ -" ÓJÖþ.�á×(¾ù FaËæÓ  K"e"# d ¤ ÄAI#MYsæC²å<"
jÎÊ@©«*WøT¸,ùý!Ž"Ü" ?ê¶º&pÔZ	¨	

ožÙ~c£ùø�ÿa¿( ± Ò þ !  È ^9:‹þ7U	^	¿ï8e‰“X›¡÷þïŠYŽöç Å!*"ý") ! µ ½ :ß©Ê);Yƒ	í	
ò Et´Ò#ƒ—ó~¨¹KP¤^Žž\„‘—µ» 6 … õ „ZÎdòìtëÅ©—O®=Ù!& Î )Kt’À™ª¶Le	l
|
‚
^²¥/-ZâG‚î"'5jU|é]!"×"%  ‚ Ñˆã+ˆŽ¡–R§ilw¥¯gkò
Š·?8EÏ Û ä O!R! C  `mÒˆ+æ;¸øEœ`Êå] _ °"' 9¨":ýXä6;ÓT	Y	‚	!
n�	¾ñî7³–ý¨¸£)‰�¾÷ƒ·ý   Í ƒc
K~•¨d	k
Q¦¤.~,Y<v¤fj!4>è^ Ú !> ‚VW}ã:ÒS	X	c	j
PUVWXY¤¥ªÂÃûüZWX”•;ãäåæabcde¥¦§·gh…†‡ˆÅö 3w] Å Æ ì"% bŽªRe
Z~«ÄýU[çñ÷mÓçáaiÇ%ÆŽxc n Ç *!~!Œ!í"! o¹æ÷þ"¡%6`¨ÿÎ…ò®øËÛDRJ�t 3 !�!v"©"" G¤.��v/
f
8õ—¾èBxí�Vy ^oÔèv“ÂÆT d È }" Fcå‡
[¬¯øm!Z{\� ñJ&üÇXy˜ o ' =«S	‘
ñÅFÓ®«ñZIèøNnÅÉéA�â bµ»jÈéÑÁ !+!î" Úpýw&¶)5�þˆ9[¯�hŠÔÜEK Ž!"›" Û Îçù‚(	#±{¢qíÿ/t �4  { ‹]¥°aÙ+ÌtØÚO˜�­£±´B €!# _ºÂÌ¹ø3Uìÿ,h7©ú FœÃÏD†ózù¿ËSºu…!w"ª"/ zˆE×¥�´	¼	0
¬
ä
B¬ßö˜C–ßÿ3Ap�ïœ@wÙn	Ç!U Þ é!ó! "l"~"  0HBjàwð,Hé	ÆS¿yîÚ¶éø—²:ÛŒÅ É  7/Ég
õ=W_dÒØ)ü”Ã?c•óö¹ ì U!  Ñy‚
´	9‡é Ž”zÌÕéúBVÃô‡0é÷«;e s!¾!õ"0 ™ ð ÿ ZgŽÆ×-hO	Ý	™
À
Ý
(,n"_à�¡Þ�©¸É ‡07ÑX†Ðz™p £!È! —5d½æˆ
Jš	[|Pò#È>ŠQC!" 
   ¢G\›­°ùæX|çMg³›ý_Ã[¹  R [ ¿ §"# ì î •ÊÌf÷Û
H13èD]zð¥§ÇNKâ'>°}Y ê ƒ! gò	Æ
7¼“Âø¯ñféOêò8BMõ¶tê�eBÌk !$ éâTÉÚE	“	’
¹
t€òYê2…;oº‘ckW¢—ÿHL. " Ä>õ³¬Q
Z
Ë
5‡G‘Îò[_bnäj�Æã¼ä»5Â ' vþ›	Ï	
ð
6_ÆwÊÔv®¬1vJùÿªÊ~/+ÉÖ§Òí,!²!ï" • è PLù	ƒ™¸›*zMë\–i–ÌÁ`Ë ×!÷!""¡" "óþ£
9²1@óGk5¿	üL© ó µ!Ð!$ qwýà~‹í
9`d“V\€¨Î ÕêÿF�©ïÎ�!˜!»!A"œ"8 Ûîÿ˜ó
xÄä?g‹—¯'6Z]�„«·ÏPS(7y6N�¯Üÿ@„‰:°ÏÚâ‚Â‹ÝãgûªÀ"#' ø=¤)	D
°
cÉ$²a|£<r{¥ØÎI… ŠŸD€¡wæ�âë&á±v! © ¦¸·øÒ	ä	%uª„¦kâ 0!½" / a x Ü b¶èƒ0 îƒ¼Ø5 ˜"Ô" Ï~®ú0^ºíM¦©Ó0K›‘­ì}³­¤ ø"#!  X | ø…	±ðš‡�±á&b¶Ú"jì,ž£QuÛ®¤C  Á^Ú¸MÍ§Omo!X" Œ¦
ÿ
ök)Ì‘NÙ\eÅPtì‘Œµ l Š!û"  XC*²Û	@‘˜¬ë'rü)’žh›¨î™«²ÃA!�!ç!ñ!'  è`#—<i¯K´G¤Êá#%ET•·êHh²”Íì’”ZŸéÖ"!†!ˆ!ï!$ ¹ Òê»�c¼ÃtùO -ƒËmú<¼—¹×o´Æ»!¡*‡1� $!N"h"†"$ qÍÍÈ
4ÇîH (ô(÷S^°¸ÀÌÑ”ßõ"3T�4vÖô®# «"K ¢iºÄô	Ô
V¾í>BET]sz•&BOpëN8€ª±éû.˜�ÄÇÐÜãøQh‡Ô&JVj˜{ôú!.:DO}v†»DvØq"x"³"ä"' ªÔ{©S|ëy±.	!	•	·	½	È	A‚­Å²—2#H°ÁÔ�€ ß ê!m""ç"7 ‘ À û {ÄØ¦� o‘‘ØÞLŸµ9	å
bvÌÞJ.–OÁ ´4�p“¼�Ý÷˜£,"âÝ!!"&"R"$ ‰œF½))Ô)•¶éB	 	‹C\æBUq>eA$BÚ]oØNy30 ò"#: ò‘Peš�ÁåË	w	1
�
­
ö
>âà÷3™Þü2D\kŒÅä»#à¼C«zð=xÄÇ•€
ÈKV i ®!Á!ô!¶") F Iñ¥Zi”áï¥ÎÝù”
4ÁÖÀðzï‹9áÈ>˜Y‘³Ü‘ á!Ï"#* æCy~ÅTcipxCVvG	p	M
fÇþåé�»ÏØÇù5@Šjnûz ˆ ’ !  á 1Ák…¥�ñ-ê	t
{K·4êÄý;dàÆÊ % $ : Ž ø/¾ÍžIIcÑ
ûÓTWfÿÈ¾qÛ›½��¤:‰Õ�K ˆ"  ' = \ ž šÖz	6
UsÍq¤`™¿>q`TÓ-ýèò@dí V!ª! ˜0APÜÙ
m*™SÝº ù ;" » ð8†ä$n
h
NïXÐáïHE€•Ä–÷Ø (!M![!t"{"% Õü@ÄÞ»ÊîÇð	S/W…Qoöƒ�×øý3eÊ	…•ÎJ¡iôY "j" ì|Ë
ý
:[ì
LŽç‘ß!f	1i±êò¬§ t!ö" �Òz£	µ	4
åíQZoÃæûÍÖûCˆÛ&!¨!¿!P" ® #œZA°»
á
3Óçô"u¬ÄET{ÜêWÄõ¾Ë<N? 1 U WŠü >ƒ—@RˆŽ»â*ciÌê>‡Ë+= ¾è	Ùù�•¶ÖÙ‡swøG f :!8"> ñ hÆì«�Ø÷.i‚½	5	S
_
Í
,Õ¢·§*Ò`²Ðô]¹áýpÆ-Š$l ª¿Ê!(aÎ]ÀÍxÑ�q "¹"% š °  ±âžs¬ò†	Á
M‰ö’ïÔ·Gd¹YˆÆ};ÒY¢šN =!¤!/"$ [ËßÇûF\ÏP	š
½
%}8w®Ü=~FÞåqæ5b‡`{% É!‹"4 %C	Þ	
\
×
Þ
ù
)-oŽü#kI‹H“À**v‘¢ÓÖß�ÞìY}Îàñƒ18Ý7Pƒ"Ì" Ö o˜(°Uˆçí‰
éŠ›ÙJÒ(Qó$±g 	Xÿ	
\uÎ3]1=?D! 6\³eÏ~
B(�µ•z‹Rb!"­" õ®¾á	KIÕ
Eý-9`œ¢VYÖ}¥ôÉ¹š    9>Þ@HLB±Íÿd"šò÷} œþ`SºÄ!  B � (©µ ]–±:Náh®÷‰¶iÉ\ "+ �b8a
©Qd
œÁú½ð-6T}æðöl+V“:¤¶`$½Ä=vç\ b Ä }!1 F£.
†
�
®ö!7ô$E–½Òç5A_w­ìþYYzŒHŸ­ÄÈè÷ÿ´ºIÁ S À ¨" Ú ÍÙø¤ü'	+E›Â.‡8y€¾ÊÓÙ°A „!* /yiÐ6	³	è	ã
«Þµþè2ùAUÂó÷–(/?±Øè~ö>‹ò ¸ ë +  í ï f–ÉË4,gN	˜
Ú
Ü
I2çß{Ýæ¦¨ÆÈO"†²á6^Z¸ ¾ ¢!¦"/ è²šfÙY
¸
Ê
5s6»4v†Éé:Í0eu^aãþñ}7LsÕãV¦þGË
±!' ø	¢
ì
ò
88_·Ãã>ŠªÎ06?xòj®Û4LÍêÙûŽ¨fú_Í¿´!Ö! ` ¥£­¶Ñ	C
bÈ×ìÍ„Ò‰ž
Cš©v¬ë|%°/! W W±	?Ùï—(!·êû(‘L�PNsªlæ!H ¸ Œhó	Ç
"½ADSry”o‚ÊlŸ®ù;°³
-£ÆÉÛ÷S”¶ÖéUgn—±Å'Ìëó -9CN|ö]·Yuô€uèC0Õ" � !!M"g") ú Ãz€êÊ” 	”	u�2‹ã±»³=’dy<GÀA× Mx/ h µ"æ"ñ"# Y�BUF	L
“
3ÀÒäeà3€ÆŽX£cÔ�J # ûï…ãÕ#mÆÛVTrP‚£÷pGSl˜ÍI”ñhL!:"s"z"/ ­ "‰›ÿ@–Ê
º
ü
óYZëQ	!n†<�ŸÞåúeøÃÕØ†SÛ½ÊrñÚ> 9!8 °ÅÊªö�¼ñ	R
[
Ì
Ö
$L|ˆõûj‘î HG’Ïó\¸ÓoÛ}‰Ò#¾ä'p|Íåð¡6<! Õ ­þ	
‰HÔØDü,}2°0ya!. A € =€ ?K´Ÿ-
À6¼ÌóD@¬ëýXy5cå!kž¬ÃÇö*ö9
ˆH¼Ã |!" .x3h™Ø²	X
·
u…šÁÌdtÞ`ý´åýç1…½ØF¡!¥"4 V¤¢¬µÐ	÷	¡
ë
ñ
7>aÇ@xnkÖ:	5w¢Ú“­è	3Tm¨ÄÌK�&Ë,\«r{§©¾.!³!å!! !þ•œ“"l
K
X¿1Š¢ö�°ßÂÚ<FRÅÖðÓð= I ð"# wÿ2	ý	

W
#GËú�íûC|Àxü «³ü081{Ì×ï{!, ¡!kö	
 
"`½¾ú0BÕ‰¡ôõ¯Ù2lwÀÁúû0QxyzÊËopq¨Õîï-!  4¼  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                       )                                                                                                                                                                                                                                                                                                                 >                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2                           )                  	                           
                                            -                                                      
                                                                    	                        
                           #   "         	            	            I   1            
      
      	                     	         	                                 
   
   &                  '   H   /      5   .      +   2   '       ­   [      )   (   "   -   &   z                    )                                                                                                                                               >                                                                                                                                                                                                                                                                                                                                  2         )      	         
                -                  
                        	        
         # "   	    	    I 1    
  
  	       	   	           
 
 &      ' H /  5 .  + 2 '   ­ [  ) ( " - & z   �  Ž‰  Ž©  �  ”ó  ›©  ¤-’ß!L
	ÃL
¶` ¤ªö	L
X
 
¡
ë
>?‰ÇÈHx¼¾¿	Ÿ°³“Û2�Ã&kÇÒNŽ<Nô³!¤AÁÇ§hx?ü#t %­"9~RÕ{y"; xq=vä™Ã8	Ð
µ7"ª‰H<çŽY²ÃÄß÷Å	8	Ð
Nå=U{æ]„±á°4=LUŽÈ$R±ÕÞBµ¾¢ |Øäõu{»&R¦é[—7"i"p"y"—"ñ”
Z6‹ïôÆ	*0¤îÀÆ	ç
*L¤Æ	*¤*Æ	*Æ	***AÖ¡@§ ÏÏ#Gïß* zèi väèï/	óR
±¨]õÍ	ï_ó]&	L««ª±sÜó·¬¨ú	)
³
�žx!ª¼\èý ¶´¨¶ äP °“	6€[é²!“	€[¬¨)
w¯É­(ªœf™?!á<ñ…„"ÿ&J	‡ >:…�@Œ¹é(Ê)OÒP¤Ï&,uo"Ç
öd¥�çð ôŠÿ˜	«›³õ@‹-#lsz 	ëÐÈâ;£.
ô–AS 
Ž (Â@MéªOÒ œf™Á?!o"(á  ,‡h
Æ¡$	ß-©ÃfïD 5"©fD 5"¢'	÷	aÇÖú	ž{
F�TìSú	;¸ÉžQ¥©BfD 5"õÌ	

Æ¡$	ú	(ž+å5Ã�t!ÙA  @éOÒo"Ã	ÎW[ #ýô ë¡Ÿ“<Öð"ßeY“F5ôš Å@é~OÒ$® o"ü JŒµ ¬¨©>Ì	ú	?
ž
³
î

:…¹�Ð@Œ¹é(Ê�žŸ)28O©ÒäïP¤Ï&Ö,JquÓüÏ!o"«½]èsþ>÷œ–± x 0˜"ê £³`ì¿
ŽzY?K£Õ		ö	÷	 
ÈÌTr×!�°±Sà2LPpÌ¾Sv'Ìæ"Pî7>ñú�Ìß» Ð•^â=‰©ÍÚØùçG®±ºnƒ�^«@1ŠÑ\—+?	ã	Þ
I‹Àx 0«@Õ}­˜"¸î�!À¾·!ÕTrpS_F
SÆ¡$	ú	;(¸ßÉž+å-Q¥©5BÃfïD 5"üì U!,Y?KÕÌTràpSæ²¾ ¦"sÜ[ 8Ýç¤“ì4	Õ
+*?âþimK†©9Fæ’±çGSÇ%xÑØñ[xå;`�" "´"¸"Õ	Tr!�SPpÌS�
< [ y	p_,©!¿ü sßôÌ	
)/A
JŒµ,­¸ + aÊSø›(2#AÜêWN÷	SÌd	k
¤Y!4è°gò	¼“¯ò8BMtB
Æ¡$	Ãâ«½];£è.
sô–AþS Pš�>Ä•C\
)*Ó8 	;"
�
6_¦ïáî<†¬
�
�²ñf#©fND 5"Ì_-h÷æÏ	tÆ‡±qyîFñ_à‘h›ý_²üÿì U!s!õ"Áê	{  ê¢Xâ©Ø	ö
3S'¼ÌCz€u" ô!¶"ˆ�Bu$Ù‡8€'	“	ö
Cz¶"(>'	á÷–œ± Ë yíA
‚®üG Ô7r ]–·êJ	³‡œ‡+"Pò «ËµBæ
ôÌ	
)A
­ tàÍ	0ï-c¹ë, zÅªêö�¼	 	”	R
Ì
�±Ïó\¸o‰#¾'GÀÍæ"ë yï¤é ‚!ÔÚÀ³`¾ì·!Od™œä	Œ
õ
ø
=Šû1¿º"))uÕBª|Íß‚ÃÆ”ÜJ­!‚"Ë"­©³ú	û	*
@
U
ž
´
é
î
¹ÇžŸ2z´ôb‘Ý®�±ÀÃÓ"3y!¢"÷	ø	¡
ë
ñ
7·5w­3LÌê§_¾³!Ö!Ù¬	eƒt �!™!‚‡éŽ”÷e ­©*
@
î
2ôb®À3Od™œäŒ
õ
=û1º"BªÃÆ”J­!	ø
Š¿))uÕ|Íß‚Ü‚"Ë"ûÆVP‚÷ÍIh5c…ˆ	9
Ãí–Y€O'M
Á#
	î–' ¶'· þ—Od™œä	Œ
õ
ø
=!CRqf�®É5\ƒŠ­û1R²¿ÅÈRµºÕ"?ƒ))uÎÕáBª{|ÍßâXó‚ÃÆ”Ü/J©Ž ­!"‚"Ë"zÅªêö�¼	 	”	÷	ø	R
¡
Ì
ë
ñ
7�·5w±­Ïó3L\¸Ìoê‰#¾'GÀÍ§_¾³!Ö!æ"?ÃÝï	.„nŽÖÉ„ X "i"ÜG
rÒ!T"ëÔ¡¶üÅkŸ¿Ì€”=dA×Mx/ ñ"#„Ñ!Å"üÇð	Wöƒ�•Jiyã
«Þþ2?Ø~ ¬Á
M¹ˆš/"¬î½�¨¥Ml	?
ì—hï
^­©V (vÓü(Š°Ÿ	¼
Š[Ø’éú�­M#\_—!º!Š" y¬ÿ	Á
ã
–M«ÞþN¹2ˆ?Ø~šD!/"‰œ)) 	CBÚoØ3#® #œA»
Ó¬ÄEÜêWÄ¾ËNÐorÂM¹’Ô#B�&qíÂð!@xnk:	¢Ú“èTmÄ&Ë,\O˜y••ö! " "d×·òv¿ã�	Ã
qeÜs�‡ÈŸ¤Ïú^M¦©ë'Krü)›ž‘«²ø"#™ ÿ z×¥�´ýÀ
ä
ÿ¸3�‡œêKÑX!™£! " -
6óD@¬ëýXyž¬ÃÇöH‰ +Ú¸Ç'
&�Ç«oƒ ’"+ bk_*:f“$·‘ÐD_ªä}9 ½!à"ô"s¼ÁÄàÃ	Ó	ÎÜ¶¢­æXç³ R ¿ §"Ã
eŸd×qÜÈ¤b:f“ª}½!ô"·òv¿ã�	s�‡· þ—!CRqf�®É5\ƒ­R²ÅÈRµÕ?ƒÎá{âXó/©Ž "® #‰œœ)A) 	»
ÓC¬ÄEÜBêWÄ¾ËÚoØ3N#ØÀÚˆ…-.f
V^“Âò¨ Ok è`#—<i¯K´G¤Êá#%ET•·êHh²”Íì’”ZŸéÖ"!†!ˆ!ï!¸ Œhó	Ç
"½ADSry”o‚ÊlŸ®ù;°³
-£ÆÉÛ÷S”¶ÖéUgn—±Å'Ìëó -9CN|ö]·Yuô€uèC0Õ" � !!M"g"þ!O—ß }˜f®±5\ƒRcFU[y§?ƒ•¾Îá•Ÿâéþî~©ò Ï!ö! ""@" "u y^&—¸ëˆK	´xàˆ¹'�ˆ,"Ø 7Ç®ó`6æ§¢ë	%	Ž
–
÷
©6¥”š3]¾ÐábDÄð¬&‹Ü;{ñÓ-[\eÉ¯!Â!·"#¡çéb»N–=Æ%AêJ—â$P–¸Ó%GIi³“R“¯ÐÞ!…3 )†×#!‡!î!p"…"Ö o˜(°Uˆçí‰
éŠ›ÙJÒ(Qó$±gy ý t] àõ·Í	*10y´äóBï�K�¶-c®¹Á„Ùë , P ™"xÈ™~³			û	U
ž
µ
é
 QºhÈ¨¬Ÿzµ‘œ´ÊÝöA�±Ðãtzƒ®ÃŒ:EW	Ó#.y!£"	#ø	¢
ì
ò
88_·Ãã>ŠªÎ06?xòj®Û4LÍêÙûŽ¨fú_Í¿´!Ö!' = \ ž šÖz	6
UsÍq¤`™¿>q`TÓ-ýèò@dí V!ª!Ø ,7ÇÜ&x®ÈÝó`™6f~±æù§@³¢ëï				%	3	°	û	
U
Ž
–
ž
µ
é
÷
 ¹)Q©ºÒáå6h¥Èø7^”š¨¬Ð3ET]lŸ¾Ð8z�µ,‘œ°´ÊÝæöA…ŠÊR�á6;bt±ÐÛãDQs¼ÄÌåð¬ &Wtzƒ‹¢®ÃÜ%;{ŒÞñ:EWqÓ-[`yÈ	?\ÇÓü#e¿É.y!¯!Â!ã!""�"£"·"	## ' = \ ž Œ˜šŸ "¸ÒÔÚ]“"$0fAP�š¢Ö—™Üz	6
ŽÜÞUsÍq¤`™¿>Oh€q`x°TlÓÙ
-m¶*çýEGI™¼èò@FSd¦Ýº í ù V!c!ª!";"="À)Ú	
þ
õ�%i«��gš§ë‹  @!ú" " Z ¾ >˜Ë<,	@	î	
ß
äJŒs”Á½ª©ínº~g�Þ8ùQE ¬!6"Í"³ Xm�ÂÏè†¦—ž¸áê)^kt{	ë	z
†|ìLwÑ_ÉíþI%WV.x3h™Ø²	X
·
u…šÁÌdtÞ`ý´åýç1…½ØF¡!¥"ôù$p®±»®¸>¥‘*	ª	=
§
±
ç
qÊ%O¶|¦ÙºJQn<¢ƒšrx� ¬œŸãsÄw!Î )Kt’À™ª¶Le	l
|
‚
^²¥/-ZâG‚î"'5jU|é]!"×"p Ø 7¯Ç®ó`©6æ€§H˜ÉžÀ)’¢×ë	%	«	Ú	
,
Ž
–
÷
þ
‘õK�©®×6¥òÿ+�”šÂ%3?]¾Ði«;cs�£·Ý�Úábgˆš§Â)DÄð¬&‹Ü;o{ñ Ó-9L[äG\ëxe‹É  ;!@!`! !¯!Â!·"ú"#Û Îçù‚(	#±{¢qíÿ/t �4   3p     R            s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘9>Åì²¤[þ1›Ó0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäsß`DÇ0øüölHómðßápÈ±8 0Á7ÿS@óaõÔaDßT3ø~´ÿŸŽÜ†œ:çÞ°ßŸôÃœEÿ¯�ÏmuÃw×6ÄRq28Ü„ëN|çðó!°Ç­BðëüAÓ!ºßFÛÍ5Ï|�7ãØeÈà€Ó¬üß­>30ç�:È t÷czÔLö÷ý6øÑpýŠÏ¯<ÈN7MwÄà6È}7>µý³ë=ó;K/ZãÈ7Ïðï|³4AK®]Œ!ÈE¿æu?pŒû=üÇ¿Ð<œßìóÌ¬ñçü÷3ÝòÆð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>µû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           •  —  ñ  	   	
  	  	  	$  	+  	-     !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ']<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7550" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6759-7550" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7551-7619" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="4318" maxFusedRunOn="4318"><Segment range="2933-3595" color="#05fd14" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="18" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3719-4318" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6000-6588" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4319-4906" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2606-2874" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4980-5213" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2382-2593" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5425-5560" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5285-5406" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7620-7724" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3715" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="4318" maxFusedRunOn="4318" detectionMode="exactProteinMatch"><Segment range="3665-3718" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5646-5652" color="#ffffff" type="standard"/><Segment range="5653-5670" color="#ffffff" type="standard"/><Segment name="-35" range="5671-5676" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5691-5712" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5622-5638" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4789" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4406" maxFusedRunOn="4406" visible="0" detectionMode="exactProteinMatch"><Segment range="4790-4801" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>a24561ae-3c25-45aa-98ef-0eafedf553e3</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="0:58:46">2023.6.7</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..8222" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..8222" colors="black"/></BottomStrand></StrandColors>  ôý7zXZ  æÖ´F !   t/å£áŸä²] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷¿Û{ãàÿæ	‚!ÜrÿÊ"8ñ`–�‹B»Ë«†·‘öK d‹·ú”§‚µüC5hi ‹“î`]µ÷;Ù�9¡FU ûûÇ7„«ê·Î’$áðCßZ-’.þ0N?ŒÎ¥5o‘ $;dhÐÃ§R�’ºÄñ.F©§œC�œèÈØª¹]'p[äŸ&Ä;“¢Œ#ÙèÔL¾Ø<
Jg“·og+¸G‡I.~„‚oèT³P'¸Â�ˆüô„»Œüð%¸:ôGôP‡h6¾ôÂ|coX�>"ðÔ„œK„vâõo¨ÚðÖ´pfÎN
œƒê6Kãh9 ¢q{p·�ÒÜ‘ï•Ð¹aÛ¿ÀŠïJÞ>~MICñN)¯ìàO´¡»ŸÌ¤†Yz°éûA}ˆµCKüÑmÆ<v­{ w[W©û˜¸;M§®—UÄ;ïQÚÒ�Óñ¾´@"6¿:i½Iåõ
_± 1¨F|Ê·™îõ"‰ÜaÔ�(ÃãÖ#cQmÁYuÄ º>7ï1ë…ò@¹ÚrMf=¿Ó‘j6'ñX÷ê
…;UwC/OÂmóÆLKìHU®AËÒà"CäZ<qt¡ÐmMj‡¯ÑoMºNR(Ï#èÓ”0±Ë\FëùT¼%òDR0ëMÑ ¹æ–ÔµùÑ�¶ì…^D£F7h¼Y—²ÀkÇkp“Æ®Óm›Ì¹9Ï®GK&�ÉÉ>~Ää‹»+ë|f¼æ¾Ä¾%RBŽ�¹ÖMô€ÒšŸ9 m‚&ªf]¸Áë‹™ÜÈóšãó%¥j_¯¢š‘PÊÕ‡á‘Šï÷!Uü�z}Â€ñYö%¬Os^sg`ÿäÿg^úb{zÓmôaš$Å®w‰ã›âMöRÆES®�?fsrA\šFá/Æ¿2>]aÑ:rÝY-�¦]¨4ã¿ž@…’‰.¯ú7¼rÉ>Ãã1Sf–ì@V•”~™ëœ
 zOú2®n“Änë¿x¾ž×:…¨Ûì[õ! p\÷²’r ‰=q.z”õŒŸqì½ôV’Žis€/ˆáIí'Ú0ïNÍ GtbzÕ¶By±^Ž.R:0j™	¾ÒÞß8¤¨Žai „DžJóŸ#¨%Ç•pµöÐ¶×¾$·F˜ê3ªð[íˆ`C�¶_ã<¥ºéu´ã:É:Ã’¨?/A¨q¸Z¯�²—äó0_å°2µ £=(U×c¦ÿÝk‹¯¡-Õ‚øëAK+˜Ã;˜1£Ö;ò/á;0è2�¡�­äYe�š’ØpIAkšóx&KB>¸…—�ä‚½X@LPZknŠ}ûÙÍlqÎ<þCžµ¯Ëc”bÊ°‰ ¿¦œS}I4Kà»zwl†ÁÅþÎ� Mžc„xfÐ\(¡îhïøµ-©¿,KÄ”zÕJ‘[5~¨9e�PôúÏ¼îìpd¢8(AÄ
§Îß$9wËÝöÌP³qÛ³’O ÊÓO\w�÷‚dòí�|€É5»™”HÚk¸íÖ´8O�é�YmG·é*ë²WR‰îŽçf S)Ó1/È>S›«¸'–F<¿!Å)œ¦3`á»îÁ4ß½;?°†<XÂg¬&ËÁo0@ºâz§ßÂ´£½"X·Ü@fšHo¿ð‰ëY…ŸÌAÙžüÂçbv¤‡éèâòQt,ÀíŸ·…Œ� pï…o9ÅŸÏÒOªñ§õWõü;Ë`QÑ¼<ÕW�¬5\Í–äBˆwÏ?UEžSÝ‹,î6�èÂ¥f^@Œ,§Ó,Ý(/çŽÊžug‡;k»×Þxý—YòÉ	Åæè”ØØwñq×†ÁÛ]øçÖ0Ä{–�¨�²m·	Vèb±ÊÙdŒZúò
:RVRw@PHñ"· »“ð°j…Ö—h:ûa®Þÿè@aòè…Ð€ÜØ�4ßÛCŸøëQk:Å–=°ÜÍb#çc©?G:ìŒ9ÙŸ,Rlm`áÉË±*Zè€íaã¹­Jà�É¬„³1™é7íø4øÏ¾w¡óÈŽ5±ÅË×FÂœg@ù@¥µˆKM°€u–?.uöÞ6 �ƒŒ$Ý¢Ä¬«j´q¶N÷5�El„ñ¤ýÍÕÊúîSËKZžÖrKØƒ> Ë LÁ¤_›võï ºì¡ÍÎ$âX0õ7š2“«í‰ ŒN
©Ð0fÅý¶ãwŸ¡Ÿ¥«Í‰
	€ùÊ�'2!	qklvëbçÊó¯¢–%ÝØHÿá48¦
œ“ˆü�h8ÎN¿w·5,ÜÕ™Dî¡h7Àª¤›ºOYqãë
FpšbÌÌÝäÎ®¶Ñv�Å?Ë¼¦½ã{“Éh$Öt�ï®aX�Ÿ"qxí ÆZ¬Õ’ïøM
PpÑki¦AûxÂ“ªZ½Å³–"žþ‰ ®lºaÒ±úì•™7=L›F9ØÒ:¦ºV?›Â_3E¦§x‡�Žk‹jþ¹¬Gå»z}_-Îÿk”ÙÑF†án¾ž€ä¨Èl ­4_ûncó‰rb¥Æ‰™ù€¾•%Ú[®Lf«6kÂSgÈuÇ`åÌÛf�q\œë‘$¬lÉï%o:\•êÍu1VE�âO¯–Rl;�/EA†rLM8*ú¢=Ÿä¡jA²ÛnÎÕ^§L|�„Q2kh Ë?xâéœ¾ð¢KÎ/ÎTz°†ZÜ%3âú5âäýÑms§9MvsßžêóT�i[»ÈÀ*Ïá„vû­£D¢¸‰>Ç4 õJÔ§V÷‚_GÝÎ=Ž‡ã*Ø®½Û` ´†%CÁÊûžFsžÜ‚PVï—K©ïf”lHôC×Jmÿ ½@Š‚:“‰Îìküd(ã¢ç çÕµ½5À5“qÉÁ‚Û{[1”§‰wS€ý¹G»âfRXG¥cdl²9�^¶üZ+–vîbþž…àèÀ²ü�czdÃd6P	+¸úÚß‘Éð •0
z8}4ØOMÕÚB^ÆŸHê)IŒÕú�Û¯Á¸ˆ/Ö#·²ìV<é~šéÒü€ðÝÂôóÎ‹ÇŠp®òoÎhµg*˜ï½¥>Q)HWmz×È–š¸s+Æ‚”øqQ`É¯€å™ÿSQqí<;ÀýÓ9×]âÛ|bI5"É¡M²=äiN‰0þNÿw>¥’Mê
‘°’EF—'¸Zo#+µ; ÂÚUŽ—“¼\iþIÕ?­åˆŠ5á¹<'l‡‘®)âqÇ ³0uM÷MkAðA³¨–­ojŒ±òm„e½ÃÒJ0<Z
bP?€‘TÈŒýÑÃOii¿ƒ“,[ËÈ¦ˆjÿ¨üïRjýH–ª¯É	^{@ŽŠ¡—â:^5"®¶õGåæªt9Ö�˜†å&¢ÌðãÍ�¿zÄóŒéææ~˜p6Úé¡›�c‹ÃÛ¹Õï›„bÑ¨t¯9Ú(è�áñéöæ±ˆHrõ¹Ã®½±üúÑ“Ši­¡E°–OÍ@œÎŽýs"˜¯JV¡EÏ«69†_æ^IR…g	Ü{ØÌ\“�$`GSÞ˜Ï Únó‚p™ë·¥ô·äÙÜk’l <žÔ-²qj[øµZuû�#þ†Ìîªæ*Ù’
iZK�-ì† ¸Õ?ÐðIÅâV6¡7n5Ö£è›2Á/ÃÌèl¥5Ÿ-2QÇc¸}èAZÞÏv·=÷>¡/Âè´V@k£û½{‡fr“:È/�ô¢Æ™ïðÇ$é%<œi¶êé·—¨ …Õ¡„Æ³Á[bvFiÐI½é'…Rìo\ŽAxòrÕµGµ
a€�èL;*‰*†ÇJöN¾>ŒLvIdˆC¾ãO]ýÕ*®Î<ÞE/†%ãØ­8ÜÛ?YÇ—­±MœÚøŒ�þÄWk—Ó„Ún4%+6ëQ¿¼?DjnóÕPVŸèåwAj‹Ì¯ÿ/åí!œ’ˆFK—ýÈ<TYÏ£®T§BíE;j`ƒIêgÏ©·‚àýßØ±s8|íÜQ¹¦·!Ç’×Å"è°Î1{±Sdv­J("(eFH²:±YÁÜçˆ¹UG@.Ã'„)õ!;`$žä<¤ñ™XïÊýôÑO'?3ÈÆkK2Õ[Ëtx<ZTù—ùÕÃÒ�Û"î¾Ï±qÊ¯»µÀ¢‡HóFñ¶ ¤€¡%¾¸z¨wÕ¹Rq¢JNÍð9$Qä¨Çß) dOò‘Š”¶|Ópl\ÙK
ÙgÃœ˜/´NÜhÁ+7K¿p‰ý>´%¡ä�°Sà…kQ™9’¦–xæï�[ãª?×°�§À#ÖH©ÛÙ@Àð›6îÎ2¶ª,¯CM:Éœ'¿y4àÆ~îfŽp’b©8±Ÿì—y$®ÓíW.Ãà[ÑæµâÞï�²_Iêé˜ÔzçwW?’Ëv°ùxQrÞ*EìØ¤¡}8øâ$É†¯Àff†K �h¡ dß·àˆ<‹«ü2k còë†æˆT¢WµXuòœï¼\†Ý¥ÊO^ÙÖ°¨¯‡u�þ%»³É=Hï°d€}¢4€ãÎÎ¿)¢m:SqÐ0·Ÿ°(     ¸˜ígôÁº Îå¿ +¢~†±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  +ï<?xml version="1.0"?><Features nextValidID="22"><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5551" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="5168" maxFusedRunOn="5168" visible="0" detectionMode="exactProteinMatch"><Segment range="5552-5563" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="6384-6400" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="6453-6474" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="6408-6414" color="#ffffff" type="standard"/><Segment range="6415-6432" color="#ffffff" type="standard"/><Segment name="-35" range="6433-6438" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="4477" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5080" maxFusedRunOn="5080" detectionMode="exactProteinMatch"><Segment range="4427-4480" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="EGRGSLLTCGDVEENPGP"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8382-8486" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6047-6168" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6187-6322" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3144-3355" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5742-5975" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3368-3636" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5081-5668" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6762-7350" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4481-5080" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="19" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="5080" maxFusedRunOn="5080"><Segment range="3695-4357" color="#05fd14" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="PAMEIECRITGTLNGVEFELVGGGEGTPKQGRMTNKMKSTKGALTFSPYLLSHVMGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVVGTGFPEDSVIFTDKIIRSNATVEHLHPMGDNVLVGSFARTFSLRDGGYYSFVVDSHMHFKSAIHPSILQNGGPMFAFRRVEELHSNTELGIVEYQHAFKTPIAFA"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8312" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7521-8312" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8313-8381" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="21" name="LINC01615" directionality="1" type="ncRNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2311-3082" color="#8fbc8f" type="standard"/><Q name="ncRNA_class"><V predef="lncRNA"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ±<Notes>
<UUID>c2b985b3-cada-4e9e-b005-43d369cb351c</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pLV3-CMV-LINC01615(human)-1-CopGFP-Puro</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="19:35:32">2025.7.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             c<StrandColors><TopStrand><ColorRange range="0..2309" colors="black"/><ColorRange range="2310..2715" colors="blue"/><ColorRange range="3082..8984" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2309" colors="black"/><ColorRange range="2310..2715" colors="blue"/><ColorRange range="3082..8984" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
